His fame reached dizzying heights when he teamed up with Senthil in the super hit blockbuster movie "Karagattakkaran".The duo's antics in the movie, the way in which Senthil always lands Goundamani in trouble or irritates him and the ever green "Valzhaipalam" joke took the Tamil Movie world by storm. It changed the career of Goundamani and Senthil. Now they were no longer just another set of comedians but an integral part of a movie's success. It was to be their first among the scores of movies they acted together, entertaining people with their hilarious comedy.
The Goundamani Senthil combination became virtually unbeatable throughout the 1990's. Any Tamil movie with both of them was bound to be a success. Some of their most famous movies include Gentleman, Indian, Nattaamai etc. Senthil would always land up Goundamani in trouble or irritate him to the maximum. Or ask some of the most stupid doubts and will end up receving kicks from Goundamani; the way they carried out their brand of comedy was very entertaining and the people lapped it up.
Goundamani also successfully teamed up with other popular heroes like Rajinikanth, Kamala Hassan, Satyraj, Karthik and Arjun. He was also very successfull with Satyaraj and both of them teamed up in many hit movies. Comedians like Vivek, Vadivel have also acted with Goundamani.
Goundamani started acting in fewer movies after 2002 and there was a period of time when he almost stopped acting. Some of his recent movies are Thangam and Suyetchai MLA in which he teams up with Satyaraj.
Recently his daughter Sunitha was married to Venkatachalam in Chennai.